[Objective] The spatio-temporal variation characteristics of temperature and precipitation in the Pearl River basin from 1993 to 2022 were analyzed, and to the future extreme climate changes were estimated and predicted,in order to provide a scientific basis for the prediction of climate change and disaster prevention and mitigation in the basin. [Methods] This study selected temperature and precipitation data from 51 meteorological stations in the Pearl River basin from 1993 to 2022 and used statistical methods such as Mann-Kendall test and ordinary Kriging interpolation to analyze the changes in temperature and precipitation. Based on the shared socioeconomic pathway 1 〔SSP1-2.6 (with a radiative forcing level of 2.6 W/m² by 2100)〕 scenario, extreme climate events during 2023—2050 were predicted. [Results] ① The temperature showed an upward trend temporally, and precipitation also showed an upward trendexcept annually and during summer. ② Spatially the temperatures were relatively uniform in winter but exhibited significant regional differences in the other three seasons. Overall, precipitation was higher in the east and southeast and lower in the west and northwest. ③ Under the SSP1-2.6 scenario, the maximum daily temperature extremes and minimum daily temperature extremes and the maximum number of consecutive rainless days showed a non-significant upward trend, and the precipitation on extremely wet days showed a non-significant downward trend during 2023—2025. ④ Spatially, the maximum daily temperature decreased from the central region to the surrounding areas, and extremely high values of precipitation on extremely wet days were observed in the central-southern region during 2023—2025. The minimum daily temperature extremes decrease from the southeast to the northwest, whereas the maximum number of consecutive rainless days decreased from the central-southern regions to other areas. [Conclusion] From 1993 to 2022 the Pearl River basin has shown a ‘warm and humid’ trend; Under the SSP1-2.6 pathway, extreme climate events will be mere complex hybrid and locally prominent during 2023—2025.