［Objective］ The regional ecosystem service value of the Huaihai economic zone was analyzed in order to provide a scientific basis for the coordinated development of the ecological economy in similar areas. ［Methods］ Taking the Huaihai economic zone as the study area， based on the PLUS model and equivalent factor method， the evolution of land-use from 2000 to 2020 in this typical inter-provincial border region were analyzed. The ecosystem service value （ESV） was assessed， and land-use patterns and ESV under different scenarios in 2030 were predicted. ［Results］ ① From 2000 to 2020， the most significant land-use change in the study area was the conversion from cultivated land to construction land. The area of converted cultivated land was 6 127.58 km²， of which 89.76% was converted into construction land. ② Under the natural development scenario， the areas of cultivated， forest， and grass lands decrease， whereas the areas of construction land， water bodies， and unused land increase. Under the economic development scenario， changes in land-use types are more pronounced than under the natural development scenario， potentially leading to adverse environmental impacts. Under the ecological protection scenario， forest， grassland， and water body areas increased， which significantly improved the ecological environment. Under the coordinated development scenario， the areas of land-use types generally fell between those of the economic development and ecological protection scenarios. ③ From 2000 to 2020， the ESV in the study area initially decreased and then increased. The ESV of most cities in the study area were lower than the average level of their respective provinces， indicating relatively slow ecological improvement. By 2030， the ESV under natural development， economic development， ecological protection， and coordinated development scenarios showed varying degrees of increase compared to 2020. The spatial distribution of the ESV was consistent with the land-use pattern， with high-value areas mainly distributed along rivers and lakes， medium-value areas scattered around high-value areas， and low-value areas concentrated in the central urban areas of cities. ［Conclusion］ In the future， cities in the Huaihai economic zone should focus on strengthening cooperation， leveraging the coordinating role of the economic zone， and achieving advantageous interactions between administrative and economic regions to promote sustainable development of regional ecosystems.