[Objective] The spatiotemporal dynamics and driving mechanisms of the eco-environment in the Liaohe River basin were revealed, and an ecological management zoning framework was established, so as to provide scientific support for regional ecological environment protection and sustainable development. [Methods] Based on the Remote Sensing Ecological Index (RSEI) from 2000 to 2022, the spatiotemporal dynamics in eco-environment quality from 2000 to 2022 were analyzed, and its key driving factors were identified. Combined with the spatial distribution pattern, change trend and driving factors of RSEI, a multi-dimensional ecological zoning framework was constructed, and the ecological management zoning of Liaohe River Basin was completed. [Results] ① The eco-environment quality in the Liaohe River Basin improved annually, with a spatial pattern of “poor in the middle, excellent in the east and west.” ② Precipitation was the primary driving factor of RSEI spatial variation, followed by land use, temperature, elevation, and slope. ③ Based on the zoning results, the entire basin can be divided into core ecological protection areas, ecological optimization areas, ecological monitoring areas, ecological restoration areas, and key ecological management areas. Core ecological protection areas are concentrated in the eastern basin, while key ecological management areas are located in the central basin. [Conclusion] From 2000 to 2022, the eco-environment quality of the Liaohe River basin continuously improved, with precipitation and land use being primary driving factors. In the future, prioritized conservation measures are needed to strengthen the protection of core ecological protection areas and more resources should be allocated to key ecological management areas.