[Objective] The changes in urban resilience and land use efficiency in Guangdong Province from 2013 to 2022 were clarified, the spatio-temporal evolution patterns, coupling coordination status, and aggregation characteristics between the two were identified, in order to provide a scientific basis for promoting the coordinated development of resilient urban construction and intensive land use in the region. [Methods] The comprehensive evaluation method based on entropy weight method and CRITIC method, super-efficiency SBM model, coupling coordination degree model and spatial autocorrelation model were used to explore the regional differences and evolution characteristics of the coupling coordination between urban resilience and land use efficiency in 21 prefecture-level cities in Guangdong Province. [Results] ① Urban resilience in Guangdong Province continuously strengthened over the study period, increasing by 43.21%. However, disparities exist in urban resilience levels among cities, with a spatial distribution pattern characterized by a gradual decreased from the core to the periphery. ② Land use efficiency exhibited increased fluctuations, rising from 0.57 to 0.65. However, land use has not yet reached DEA optimality, and most prefecture-level cities display significant interannual volatility in land use efficiency. The spatial distribution pattern follows the trend of higher values in the Pearl River Delta and Western Guangdong, and lower values in Northern and Eastern Guangdong. ③ The overall coupling between urban resilience and land use efficiency was favorable and stable, with a strong positive correlation. The coupling coordination level had improved across the province, transitioning from the initial coordination stage to the intermediate coordination stage. ④ Spatially, a positive correlation existed between urban resilience and land use efficiency. However, localized agglomeration characteristics were not prominent. [Conclusion] To promote coordinated regional development of Guangdong Province, efforts should focus on strengthening the integration of resilient city construction and land spatial planning, optimizing policy direction, enhancing regional planning coordination, fostering complementary advantages among cities, and improving agglomeration efficiency.