Abstract:[Objective] The spatial and temporal characteristics of ecological environment quality and its driving factors in the Weihe River basin from 2000 to 2020 was analyzed in order to provide theoretical reference for the sustainable development and ecological civilization construction in the basin. [Methods] The remote sensing ecological index (RSEI) was built based on Google Earth Engine platform to dynamically evaluate the change of ecological environment quality in the Weihe River basin from 2000 to 2020 and the impact of climate, vegetation, terrain, soil and social-economic factors on ecological environment quality was explored based on the optimal parameter geographic detector model. [Results] ① From 2000 to 2020, the quality of the Weihe River basin ecological environment continuously improved and the difference in ecological environment quality within the region increased. The ecological environment quality grade was mainly poor and relatively poor, accounting for more than 60% of the total area. In 20 years, the area of ecological environment quality grade increased for medium, good, and excellent. ② The quality grade of the ecological environment had a spatial distribution pattern of “higher in the south and lower in the north, higher and lower in the east and the west”. The area of poor grade ecological environment was the largest, and 73.43% of the Weihe River basin was in the area of ecological environment quality increase, with an increase area of 1.21×105 km2. During the study period, the area where the ecological environment quality increases was increasing and the reduced area was decreasing, and the overall ecological environment quality of the research area was positively developing. The area with excellent ecological environment quality distributed along the southeast-northwest direction. [Conclusion] Rainfall, elevation, and soil organic carbon content were the main factors affecting the ecological environment quality of the Weihe River Basin. In the process of improving the ecological environment quality of the Weihe River Basin, the distribution law of slope should be fully considered to optimize the governance scheme.