[Objective] To analyze the spatio-temporal characteristics and influencing factors of green use efficiency of cultivated land in Guangxi, and reveal the spatio-temporal evolution characteristics of influencing factors of green use efficiency of cultivated land, so as to provide basis for promoting high-quality development of cultivated land and realizing high efficiency of agricultural production. [Methods] An index system was constructed based on the panel data of 14 cities and regions from 2010 to 2021. The super-efficiency SBM model was used to estimate the green use efficiency of cultivated land, and the spatiotemporal distribution pattern and evolution trend were visualized by ArcGIS analysis tool, and the spatiotemporal heterogeneity of influencing factors was revealed by GTWR model. [Results] (1) In terms of time, the green use efficiency of cultivated land in Guangxi showed a steady increase from 0.71 in 2010 to 0.96 in 2021, with an increase of 35.21%, but it had not yet reached the optimal state. There are significant differences in the evolution characteristics of efficiency curves in different cities. (2) In terms of space, the efficiency of each city is not balanced, with the difference of "high in south and low in north" gradually narrowing, and the difference of "high in east and low in west" being significant. (3) Analysis results of impact factors: Multiple cropping index (0.73) > agricultural machinery input intensity (-0.39) > urban-rural income gap (-0.34) > crop planting structure (-0.19) > per capita GDP (0.14). Multiple cropping index had a positive impact on all cities, and the per capita GDP was mainly positive. Crop planting structure, urban-rural income gap and agricultural machinery input intensity had negative effects. [Conclusion] There are significant spatio-temporal differences in the green use efficiency of cultivated land in Guangxi, and the impact of multiple cropping index, agricultural machinery input intensity and urban-rural income gap is strong. It is suggested that in the future, agricultural characteristics and potential of different regions should be deeply explored, regional cooperation and coordinated development should be strengthened, and strategies for improving green use efficiency of cultivated land should be differentiated to comprehensively improve the green use efficiency of cultivated land in Guangxi.