[Objective] The spatial agglomeration characteristics of coupling coordination in He'nan Province were explored, and relevant development suggestions were put forward to provide a scientific reference for the sustainable urban development in He'nan Province.[Methods] An urbanization and ecological environment evaluation system and an improved coupling coordination degree model were used to study the level of urbanization and eco-environmental development and coupling coordination in He'nan Province from 2008 to 2018, and to analyze the spatial-temporal pattern of coupling coordination degree for 17 prefecture level cities in He'nan Province.[Results] From 2008 to 2018, the coupling degree values were all above 0.9 and were in the high coupling level. The coupling coordination degree exhibited a fluctuating upward trend. The urbanization level of most cities was lower than the level of ecological environment. The coupling coordination degree of urbanization and ecological environment in each city could be characterized as basically uncoordinated, basic coordination, coordination, or advanced coordination. There was a spatial positive correlation between urbanization and ecological environment coupling coordination, with clustering characteristics of high coupling coordination in the western and central regions and low coupling coordination in the southeast.[Conclusion] The overall urbanization process of He'nan Province is accelerating, and the economic urbanization and ecological environment pressure are having an important impact on the two major systems of urbanization and ecological environment. It will be necessary to strengthen the development of the central city of in Zhengzhou City and to promote the development of other cities in Southeast He'nan Province.