[Objective] The decoupling relationship between regional economic growth and land resource utilization in Beibu Gulf economic zone of Guangxi Zhuang Autonomous Region was analyzed to reveal the spatial evolution law of the decoupling degree, in order to provide a scientific basis for the coordinated development of regional economic growth and land resource utilization.[Methods] The Tapio decoupling model was used to quantitatively evaluate and comprehensively analyze the decoupling degree and the spatial-temporal evolution of land resource utilization and economic growth in the economic zone from 2007 to 2016.[Results] The land use and economic growth in Beibu Gulf economic zone were basically in a state of decoupled, and there was a trend from weak decoupling to strong decoupling. From the perspective of industrial type, the primary industry GDP and cultivated land were mainly strong decoupling and accompanied by weak decoupling and expansion coupling. The primary industry GDP and forest land were mainly weak decoupling and showed a trend from weak to strong decoupling. The second and third Industry GDP were always in a weak decoupling state with the construction land.[Conclusion] To realize the sustainable decoupling of land use and economic growth in Beibu Gulf economic zone, we should not only continue to optimize the industrial structure, but also focus on the optimization of land space from the perspective of global and regional coordination development, and comprehensively build ecological space, achieve the coordinated development of economic growth and land use by improving the comprehensive development capacity of marine resources.