[Objective] To explore the spatial differences about relevance between scientific-technical innovation and sustainable development of China National Sustainable Communities(CNSCs) in different regions, and to provide decision reference for sustainable development of Shandong Province.[Methods] By selecting 29 index from two aspects of scientific-technical innovation and sustainable development, using grey correlation model calculated the correlation degree of scientific-technical innovation with sustainable development degree and coordination degree of CNSCs in eastern, central and western of Shandong Province in 2009-2015, calculated and classified correlation coefficient of scientific-technical innovation with subsystem development degree, sustainable development degree and coordination degree of every CNSCs in 2015.[Results] There was a high relevance between scientific-technical innovation and sustainable development degree in CNSCs of three region, showed the ladder distribution from west to east. A low relevance between scientific-technical innovation and coordination degree, showed the pattern of "high in the middle and low in the two ends"; There had a significant relevance of every CNSCs, and scientific-technical innovation made contributions to the promotions of economy, society and environment coordinated and sustainable development, but it focused on different aspects. The differences of correlation coefficient is obvious between scientific-technical innovation with sustainable development degree and coordination degree, the east is mainly moderate correlation type and high correlation type, the center is mainly high correlation type, the west belongs to high correlation type.[Conclusion] There was great difference in the spatial differences about relevance between scientific-technical innovation and sustainable development of CNSCs, and it was necessary to explore path which suits for local conditions.