[Objective] Land use was studied based on landscape ecological security pattern to provide a scientific basis for relieving the contradiction between the increasing population and limited land, and for economic development and ecological protection. [Methods] Mianzhu City of Sichuan Province which located in the transition zone from Chengdu plain and Longmen mountain was took as a case study, where the land use change and its terrain factors response were extracted and analyzed from 1995 to 2015, based on remote sensing imagery, technology of remote sensing and GIS. To achieve the goal of ecological land protection, terrain and land cover types were selected as resistance factors, the minimum cumulative resistance model was applied to landscape ecological security pattern based on GIS spatial analysis method. Upon the spatial overlay analysis of land use status and landscape ecology security patterns in Mianzhu City by GIS, land resources in different levels of landscape security were divided. [Results] Land resources of landscape security included priority, appropriate, limited, prohibited development, having acreages of 7 218.39, 17 974.75, 21 545.39, 77 791.46 hm², respectively. The corresponding planning of land resources development and utilization was put forward based on the analysis of characteristics of each type land use in study area. The results can provide effective methods and means for regional ecological safety and reasonable development and utilization of land resources. [Conclusion] The land use planning whereon proposed by different ecological security level based on the theory of landscape ecological pattern and the corresponding method are conducive to regional ecological security protection and sustainable utilization of land resources.