Based on the GIS, the geographic database was constructed through metrological data analysis, field survey, filed sampling and laboratory analysis, digital elevation model(DEM) calculation, remote sensing interpretation. The soil erosion amount in the Danjiangkou reservoir region was evaluated with the universal soil loss equation(USLE). The economic loss of annual soil erosion was evaluated(with constant price in 1990) by applying market value approach, opportunity cost method and shadow engineering price method. The results showed that the average annual soil erosion modulus was 2394 t/(km²·a). After converting the annual soil nutrient loss to standard chemical fertilizer(i.e. Diammonium phosphate and Potassium chloride) and fuel wood with some conversion coefficients, the corresponding economic loss of total N, total P, total K and soil organic matter were 1.64×10⁸,7.25×10⁷, 1.17×10⁷ and 2.97×10⁷ yuan, respectively. The annual average soil erosion loss was almost euqual to 61.94 km² land abandoned, and the economic loss was 3.71×10⁷ yuan. The economic losses of water conservation decreased, silt retention and sediment deposition, which were caused by soil erosion. were 3.22×10⁵, 1.88×10⁷ and 1.95×10⁶ yuan respectively. Total annual economic loss of soil erosion in the area reached up to 1.50×10⁹ yuan, in which the nutrient loss was accounting for 96.11%.