The coordination of land use system of Yangzhou City was evaluated by using coordination calculating model which based on the theory of information entropy. The results indicated that from 1996 to 2010, the developing level of land use system and economy, society and environment sub-systems of Yangzhou City improved gradually, and the gap among three sub-systems reduced gradually, and developing level of three subsystems all reached beyond 0.5 in 2010, which meant a middle developing level. At the same time, land use system coordination level increased continually, from near maladjustment level in 1996 to middle coordination level in 2010, but it was still in a lower coordination level. For the restrictive factors which affected the development of land use system, new general land use planning of Yangzhou City should adopt corresponding measures to make land use system coordination level improed further.