The slope land efficient agriculture developments are facing with the problems such as water shortage and poor water quality in the Loess Plateau region. Based on the concept of rainfall runoff regulation and water and soil resources efficient utilization, an ecological environmental protection and efficient water filter system was designed through taking account of different characteristics of biological and physical purification, and was verified using experiment measured data. Results showed that the maximum total phosphorus and sediment interception effect of the filter system which used energy grass(Panicum virgatum) as vegetation filtering belt combined with filtration pool system reached 93.6% and 98.62% respectively, and the biggest interception effect of COD(chemical oxygen demand) reached 56%. Panicum virgatum filtering belt in the system had an obvious interception effect for sediment and pollutant. The sand filtration pool with different particle size combination had higher interception efficiency for straw under the vegetation zone, and it made the system greatly simplified, and reduced the cost significantly. The system was able to be used for high-efficient agricultural water resource purification in the Loess Plateau.