Ecological control to the slope of spoil ground is the key project of environmental protection in expressway construction. The monitoring experiment for soil and water loss in the spoil ground of Beijing-Zhuhai expressway’s south section within the boundary of Guangdong Province was conducted to study the soil and water loss, ecological control and application effects of the slopes of spoil ground. Results showed that soil and water loss was serious, and soil erosion modulus was about 32 360 t/(km²·a) on spoil ground. Moreover, distinct gully erosion was observed on the slope. Soil and water conservation effects from using Vetiveria zizaniodes to protect the slope were significant. Soil loss from the slope where Vetiveria zizaniodes grows decreased by 92.24 %, and the slope was stable compared with the control plots. To a certain extent, using Vetiveria zizaniodes to protect slope can replace the slope protection measure of planting grass in mortar-rubble skeleton. Therefore, it is feasible to popularize Vetiveria zizaniodes cultivation to protect the slope of spoil ground along the expressway.