[Objective] To explore the change and the driving factors of landscape pattern in Hohhot City of Inner Mongolia Autonomous Region in order to provide theoretical support for the sustainable development of economy and society and the sustainable utilization of regional water resources in the study area.[Methods] In support of ArcGIS and Fragstats, this paper studied the land use/cover change and landscape pattern in a watershed of semi-arid region, Huhhot City in the past 20 years(1990-2010), based on three issues of remote images in 1990, 2000 and 2010.[Results] ① Land use types changed obviously in the past 20 years in the study area. The areas of cultivated land and forest land increased; and the area of grassland decreased; while the water area remained the same, although it experienced a process of changing from decreased to increased. ② The diversity of landscape structure, the number of type patches, and the degree of fragmentation all increased. ③ The changes of land use/cover and landscape pattern in the study area were the result of the interaction of human factors and climatic factors. The first and the second principal component were human factors, and the third principal component is the natural factor. The contributions of the 3 principal components to land use & landscape pattern were 51.34%, 23.49% and 10.90% respectively.[Conclusion] Human factors, policy factors had their direct impact effect. Land use/landscape pattern change was mainly caused by the factors of human activities and climate change, such as the cultivated land area, population, GDP, the primary industry production value, and the rainfall. The contribution of climate factor was not as large as the one of human influence, especially for policy factor, its effect is direct and large.